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Prednisone is a drug for the treatment of inflammatory and post-operative period.
One of the most commonly prescribed anti-inflammatory drugs is Prednisone. In some cases, this tool is indispensable, and it is sometimes even able to save a person’s life. It is used to treat both children and adults. Prednisone is available in various dosage and dosage forms. Any patient should know not only the merits of the drug and its indications, but also its disadvantages and side effects.
Prednisone can be bought at a pharmacy or ordered at an online pharmacy at an affordable price.
Prednisone is a synthetic analogue of the adrenal hormone-hydrocortisone and has a similar effect.
The main functions of the drug:
anti-inflammatory, immunosuppressive, anti-allergic, anti-shock.
The mechanism of action of the drug is still not exactly established. We can only say that it affects almost all stages of the inflammatory process, suppresses the synthesis of inflammatory mediators – cytokines and histamine, prevents the migration of cells of the immune system.
Any medication, which is a part of Prednisone, affects special glucocorticosteroid receptors located in various tissues. Many of these receptors are in the liver tissue.
Prednisone reduces the permeability of cell walls and has a moderate vasoconstricting effect. It also affects the metabolism-lipids, proteins, carbohydrates, sodium and calcium ions, retains water in the body.
Composition and form of issue
Prednisone is made in pills, solution for injections and ointments. The main ingredient is Prednisolone.
Indications for use
Prednisone is used for treating insufficiency of the adrenal cortex, congenital adrenal hyperplasia, subacute thyroidin, contact dermatitis, serum sickness, seasonal or permanent allergic rhinitis, angioneurotic edema, rheumatoid arthritis, spondylarthritis, exacerbations of gout, myocarditis, dermatomyositis, systemic lupus erythematosus, systemic sclerosis, nodular periarteritis, polychondritis recurrent, systemic vasculitis, exfoliative dermatitis, severe seborrheic dermatitis, pemphigus, severe forms of psoriasis. Its use is advisable in the treatment of autoimmune diseases, inflammatory lesions of the joints, eye diseases, respiratory and liver diseases, as well as cardiovascular, neurological and oncological diseases.
Prednisone is often used in transplantology to prevent rejection reactions.
Prednisone is not prescribed if the patient has a gastric ulcer or duodenal ulcer, renal failure, osteoporosis, predisposition to thrombembolia, severe hypertension, shingles, chickenpox and Cushing’s syndrome.
Use during pregnancy and breast-feeding.
Prednisone can be used in the treatment of pregnant women, but only for strict medical indications and under medical supervision.
When using the drug in the treatment of lactating women, it is necessary to make sure that the breast-fed child does not suffer from hyperbilirubinemia.
Dosage and reception
Prednisone pills are taken orally, without chewing. In each case, the dose is selected individually. When choosing a dose, you should necessarily take into account the circadian rhythm of secretion of glucocorticoids in the body. That’s why, 2/3 of the daily dose or the entire dose is recommended to be taken in the morning and 1/3 of the dose in the evening. Once the drug is removed, there is a gradual reduction in dosage prior to complete cessation of the drug.
Adult patients take this drug in the treatment of acute conditions, the drug is prescribed at the starting dose of 20 to 30mg, daily maintenance dose is from 5 to 10mg. If necessary, the initial daily dose can be from 15 to 100mg.
The drug is prescribed for children at the dosage of 1 or 2mg per kg of body weight, and the maintenance dose for children is from 300 to 600µg per kg of body weight of the child. The daily dose in the treatment of children should be divided into 4 or 6 doses.
The risk of Prednisone overdose increases significantly with long-term administration of the drug in high doses. If there is an overdose, then there is an increase in blood pressure, the occurrence of peripheral edema and increased side effects.
It is recommended to have temporary cessation of medication and adjustment of dosage for stabilization of the condition.
Obesity may develop with long-term use of Prednisone, also hemorrhagic pancreatitis, menstrual cycle disorders, ulceration of the digestive tract, reduced immunity, increased blood clotting, mental disorders and “withdrawal” syndrome.